Fri Jul 15 2022

48 articles - From Friday Jul 08 2022 to Friday Jul 15 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Impact of Hepatitis C Treatment Uptake on Cirrhosis and Mortality in Persons Who Inject Drugs : A Longitudinal, Community-Based Cohort Study.

Many community-based PWID in Baltimore are receiving HCV treatment, which is associated with sharp decreases in liver disease and mortality. Additional efforts will be needed to reduce residual barriers to treatment and to eliminate HCV as a public health threat for PWID. Primary funding source National Institutes of Health.

Pubmed   Journal   ReadQx 

Long-Term Services and Supports for Older Adults: A Position Paper From the American College of Physicians.

However, the LTSS sector faces several challenges, including keeping patients and staff safe during the COVID-19 pandemic, workforce shortages, quality problems, and fragmented coverage options. In this position paper, the American College of Physicians offers policy recommendations on LTSS coverage, financing, workforce, safety and quality, and emergency preparedness and calls on policymakers and other stakeholders to reform and improve the LTSS sector so that care is high quality, accessible, equitable, and affordable.

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Lancet

Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial.

The additional information from our study should inform guidelines to recommend bridging therapy as standard treatment. Funding Australian National Health and Medical Research Council and Stryker USA.

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Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial.

These results do not support omitting intravenous alteplase before thrombectomy in eligible patients. Funding Medtronic and University Hospital Bern.

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N Engl J Med

A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection.

Human adenovirus viremia was present in the majority of children with acute hepatitis of unknown cause admitted to Children's of Alabama from October 1, 2021, to February 28, 2022, but whether human adenovirus was causative remains unclear. Sequencing results suggest that if human adenovirus was causative, this was not an outbreak driven by a single strain. (Funded in part by the Centers for Disease Control and Prevention.).

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Aflibercept Monotherapy or Bevacizumab First for Diabetic Macular Edema.

In this trial of treatment of moderate vision loss due to diabetic macular edema involving the center of the macula, we found no evidence of a significant difference in visual outcomes over a 2-year period between aflibercept monotherapy and treatment with bevacizumab first with a switch to aflibercept in the case of suboptimal response. (Funded by the National Institutes of Health; Protocol AC ClinicalTrials.gov number, NCT03321513.).

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Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause.

In this series involving 44 young children with acute hepatitis of uncertain cause, human adenovirus was isolated in most of the children, but its role in the pathogenesis of this illness has not been established.

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Overall Survival with Brentuximab Vedotin in Stage III or IV Hodgkin's Lymphoma.

Patients who received A+AVD for the treatment of stage III or IV Hodgkin's lymphoma had a survival advantage over those who received ABVD. (Funded by Takeda Development Center Americas and Seagen; ECHELON-1 ClinicalTrials.gov number, NCT01712490; EudraCT number, 2011-005450-60.).

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Trial of Erythropoietin for Hypoxic-Ischemic Encephalopathy in Newborns.

The administration of erythropoietin to newborns undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy did not result in a lower risk of death or neurodevelopmental impairment than placebo and was associated with a higher rate of serious adverse events. (Funded by the National Institute of Neurological Disorders and Stroke; ClinicalTrials.gov number, NCT02811263.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Intern Med

Bipolar Disorder.

Thus, screening in these high-risk groups is indicated. Effective treatments exist, and many can be safely and effectively administered by primary care clinicians.

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Lancet

Accelerating pooled licensing of medicines to enhance global production and equitable access.

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Effectiveness of vaccination mandates in improving uptake of COVID-19 vaccines in the USA.

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International law reform for One Health notifications.

We examine existing international legal frameworks, and provide clarity on what a successful One Health approach to proposed international law reforms-including a pandemic treaty and amendments to the International Health Regulations-would require. In particular, we focus on how a treaty would provide opportunities to simultaneously expand reporting obligations, accelerate the sharing of scientific discoveries, and strengthen existing legal frameworks, al while addressing the most complex issues that global health governance currently faces.

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N Engl J Med

A Better Treatment for Advanced-Stage Hodgkin's Lymphoma?

Pubmed   Journal   ReadQx 

Acute Hepatitis in Children in 2022 - Human Adenovirus 41?

Pubmed   Journal   ReadQx 

Audio Interview: Covid-19 Vaccines and the FDA.

Pubmed   Journal   ReadQx 

Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition.

Pubmed   Journal   ReadQx 

Evidence for Step Therapy in Diabetic Macular Edema.

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Setting the Benchmark for KRASG12C -Mutated NSCLC.

Pubmed   Journal   ReadQx 

Targeting Oncogenic RAS Protein.

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Letters&Replies

Letters to the editors and authors’ replies

Ann Intern Med

Update Alert 11: Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers.

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Lancet

Breakthrough SARS-CoV-2 infections during periods of delta and omicron predominance, South Africa.

Pubmed   Journal   ReadQx   PMC

Challenges en route to polio eradication.

Pubmed   Journal   ReadQx 

Perilous two-tier COVID-19 global vaccine roll-out.

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Reforms to accelerated approval of new medicines: long overdue.

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SOS Brazil: democracy under attack.

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Tachi Yamada: a missed global health leader.

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Tobacco company funding and conflict of interest.

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N Engl J Med

Geographic Disparities in Rising Rates of Firearm-Related Homicide.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

Annals Graphic Medicine - Aware.

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Lancet

"Chaos" for patients and providers after US abortion ruling.

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6 million female health workers are unpaid or underpaid.

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Eosinophilic gastroenteritis with ascites: an enigmatic diagnosis.

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Improving access to contraception and abortion in Romania in the context of the conflict in Ukraine.

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Intravenous thrombolysis before thrombectomy for acute ischaemic stroke.

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Kwaku Ohene-Frempong.

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Leandro Mena: advancing sexual health in the USA.

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The Health and Care Act 2022: challenges and priorities for embedding research in the NHS.

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Use the remaining carbon budget wisely for health equity and climate justice.

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Visa bureaucracy causing GPs to leave the UK.

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We need to make sure telecommuting does not exacerbate gender disparity.

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N Engl J Med

"REACHing" for Equity - Moving from Regressive toward Progressive Value-Based Payment.

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Case 21-2022: A 17-Year-Old Girl with Fever and Cough.

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Confronting Health Worker Burnout and Well-Being.

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Drug Reaction with Eosinophilia and Systemic Symptoms.

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Pneumolabyrinth and Pneumocochlea.

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Tackling Implicit Bias in Health Care.

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The End of Roe v. Wade - States' Power over Health and Well-Being.

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